Preferred Name |
Cisplatin |
|
Synonyms |
|
|
Definitions |
An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C376 |
|
Accepted_Therapeutic_Use_For |
metastatic testicular cancer; ovarian cancer; head and neck cancer; breast cancer; Hodgkin's and non-Hodgkin's lymphoma; myeloma and melanoma |
|
ALT_DEFINITION |
A drug used to treat many types of cancer. Cisplatin contains the metal platinum. It kills cancer cells by damaging their DNA and stopping them from dividing. Cisplatin is a type of alkylating agent. |
|
CAS_Registry |
15663-27-1 |
|
CHEBI_ID |
CHEBI:27899 |
|
Chemical_Formula |
2Cl.Pt.2H3N |
|
code |
C376 |
|
Contributing_Source |
CTRP FDA PCDC |
|
definition |
An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. |
|
Display_Name |
Cisplatin |
|
FDA_UNII_Code |
Q20Q21Q62J |
|
in_subset |
http://purl.obolibrary.org/obo/NCIT_C179531 http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C177406 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C179478 http://purl.obolibrary.org/obo/NCIT_C157711 |
|
Is_PCDC_GCT_Permissible_Value_For_Variable | ||
Is_Value_For_GDC_Property | ||
label |
Cisplatin |
|
Legacy Concept Name |
Cisplatin |
|
Maps_To |
Cisplatin |
|
NCI_Drug_Dictionary_ID |
39515 |
|
NSC Number |
119875 |
|
PDQ_Closed_Trial_Search_ID |
39515 |
|
PDQ_Open_Trial_Search_ID |
39515 |
|
Preferred_Name |
Cisplatin |
|
prefixIRI |
NCIT:C376 |
|
prefLabel |
Cisplatin |
|
Semantic_Type |
Pharmacologic Substance Inorganic Chemical |
|
UMLS_CUI |
C0008838 |
|
subClassOf |