loading...| Preferred Name |
Busulfan |
|
| Synonyms |
|
|
| Definitions |
A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C321 |
|
| Accepted_Therapeutic_Use_For |
Bone marrow disorders; chronic myelogenous leukemia; palliative; neoadjuvant to allogeneic hematopoietic progenitor cell transplantation; neoplastic meningitis; primary brain malignancies |
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called alkylating agents. |
|
| CAS_Registry |
55-98-1 |
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| CHEBI_ID |
CHEBI:28901 |
|
| Chemical_Formula |
C6H14O6S2 |
|
| code |
C321 |
|
| Contributing_Source |
CTRP FDA PCDC |
|
| definition |
A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04) |
|
| Display_Name |
Busulfan |
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| FDA_UNII_Code |
G1LN9045DK |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C174019 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C157711 |
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| Is_PCDC_AML_Permissible_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Busulfan |
|
| Legacy Concept Name |
Busulfan |
|
| Maps_To |
Busulfan |
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| NCI_Drug_Dictionary_ID |
41947 |
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| NSC Number |
750 |
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| PDQ_Closed_Trial_Search_ID |
41947 |
|
| PDQ_Open_Trial_Search_ID |
41947 |
|
| Preferred_Name |
Busulfan |
|
| prefixIRI |
NCIT:C321 |
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| prefLabel |
Busulfan |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0006463 |
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| subClassOf |