Preferred Name |
Natural Killer Cell |
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Synonyms |
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Definitions |
Natural killer cells are cells that resemble large granular lymphocytes. They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94. These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization. |
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ID |
http://purl.obolibrary.org/obo/NCIT_C12536 |
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ALT_DEFINITION |
A type of immune cell that has granules (small particles) with enzymes that can kill tumor cells or cells infected with a virus. A natural killer cell is a type of white blood cell. Cells resembling large granular lymphocytes that do not express markers of either T or B cell lineage. These cells express Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody, and may occur without previous sensitization. |
|
code |
C12536 |
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Contributing_Source |
CDISC CTRP |
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definition |
Natural killer cells are cells that resemble large granular lymphocytes. They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94. These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization. |
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Display_Name |
Natural Killer Cell |
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in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C78734 http://purl.obolibrary.org/obo/NCIT_C66830 |
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label |
Natural Killer Cell |
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Legacy Concept Name |
Natural_Killer_Cell |
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Preferred_Name |
Natural Killer Cell |
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prefixIRI |
NCIT:C12536 |
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prefLabel |
Natural Killer Cell |
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Semantic_Type |
Cell |
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UMLS_CUI |
C0022688 |
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subClassOf |