Preferred Name

Natural Killer Cell

Synonyms
Definitions

Natural killer cells are cells that resemble large granular lymphocytes. They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94. These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization.

ID

http://purl.obolibrary.org/obo/NCIT_C12536

ALT_DEFINITION

A type of immune cell that has granules (small particles) with enzymes that can kill tumor cells or cells infected with a virus. A natural killer cell is a type of white blood cell.

Cells resembling large granular lymphocytes that do not express markers of either T or B cell lineage. These cells express Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody, and may occur without previous sensitization.

code

C12536

Contributing_Source

CDISC

CTRP

definition

Natural killer cells are cells that resemble large granular lymphocytes. They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94. These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization.

Display_Name

Natural Killer Cell

in_subset

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C78734

http://purl.obolibrary.org/obo/NCIT_C66830

http://purl.obolibrary.org/obo/NCIT_C142799

http://purl.obolibrary.org/obo/NCIT_C61410

label

Natural Killer Cell

Legacy Concept Name

Natural_Killer_Cell

Preferred_Name

Natural Killer Cell

prefixIRI

NCIT:C12536

prefLabel

Natural Killer Cell

Semantic_Type

Cell

UMLS_CUI

C0022688

subClassOf

http://purl.obolibrary.org/obo/NCIT_C39568

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CL_0000623 MAXO LOOM
http://purl.obolibrary.org/obo/CL_0000623 CL LOOM
http://purl.obolibrary.org/obo/CL_0000623 MAXO LOOM
http://purl.obolibrary.org/obo/CL_0000623 OBA LOOM
http://purl.obolibrary.org/obo/CL_0000623 EFO LOOM
http://purl.obolibrary.org/obo/TAO_0009278 TAO LOOM
http://purl.obolibrary.org/obo/BTO_0000914 DTO LOOM
http://purl.obolibrary.org/obo/BTO_0000914 BTO LOOM
http://purl.obolibrary.org/obo/ZFA_0009278 ZFA LOOM
http://purl.obolibrary.org/obo/ZFA_0009278 UPHENO LOOM
http://purl.obolibrary.org/obo/ZFA_0009278 ZP LOOM
http://www.case.edu/EpilepsyOntology.owl#NaturalKillerCell EPSO LOOM
http://www.co-ode.org/ontologies/galen#NaturalKillerCell GALEN LOOM
http://purl.org/sig/ont/fma/fma63147 FMA LOOM
http://purl.obolibrary.org/obo/CL_0000623 CLO LOOM
http://purl.obolibrary.org/obo/CL_0000623 HOIP LOOM
http://purl.obolibrary.org/obo/CL_0000623 CHEAR LOOM
http://purl.obolibrary.org/obo/CL_0000623 OBI_BCGO LOOM
http://purl.obolibrary.org/obo/CL_0000623 DOID LOOM
http://purl.obolibrary.org/obo/CL_0000623 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CL_0000623 COVID-19 LOOM
http://purl.obolibrary.org/obo/CL_0000623 PCL LOOM
http://purl.obolibrary.org/obo/CL_0000623 HHEAR LOOM
http://purl.obolibrary.org/obo/CL_0000623 UPHENO LOOM
http://purl.obolibrary.org/obo/CL_0000623 NIFSTD LOOM
http://purl.obolibrary.org/obo/CL_0000623 KTAO LOOM
http://purl.obolibrary.org/obo/CL_0000623 IDOMAL LOOM
http://purl.obolibrary.org/obo/CL_0000623 CCF LOOM
http://purl.obolibrary.org/obo/CL_0000623 IDODEN LOOM
http://www.projecthalo.com/aura#Natural-Killer-Cell AURA LOOM
http://purl.org/obo/owlapi/fma#FMA_63147 BIOMODELS LOOM
http://purl.obolibrary.org/obo/LMMA_00245 LUNGMAP_M_CELL LOOM
http://purl.obolibrary.org/obo/LMMA_00245 LUNGMAP-MOUSE LOOM
http://purl.obolibrary.org/obo/TXPO_0001526 TXPO LOOM
http://purl.obolibrary.org/obo/XAO_0003156 XPO LOOM
http://purl.obolibrary.org/obo/XAO_0003156 UPHENO LOOM
http://purl.obolibrary.org/obo/XAO_0003156 XAO LOOM
http://purl.obolibrary.org/obo/VHOG_0001697 VHOG LOOM
https://go.drugbank.com/drugs/DB15721 MDM LOOM
http://purl.obolibrary.org/obo/LMHA_00245 LUNGMAP_H_CELL LOOM
http://purl.obolibrary.org/obo/LMHA_00245 LUNGMAP-HUMAN LOOM
http://purl.bioontology.org/ontology/CSP/0435-4050 CRISP LOOM
http://purl.org/obo/owl/CL#CL_0000623 BIOMODELS LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12536 NCIT LOOM