loading...| Preferred Name | Cisplatin | |
| Synonyms |
|
|
| Definitions |
An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C376 |
|
| definition |
An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. |
|
| isDefinedBy | ||
| label |
Cisplatin |
|
| prefixIRI |
ncit:C376 |
|
| prefLabel |
Cisplatin |
|
| seeAlso |
EuroCAT Umbrella Protocol for NSCLC |
|
| subClassOf |