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Last uploaded: August 28, 2024

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Preferred Name	cisplatin
Synonyms	Platamine cis-DDP Platinol- AQ CACP cis-platinous diamine dichloride Cysplatyna DDP Platistin Briplatin cis-platinum platinum diamminodichloride cis-platinum II Platiblastin Platosin Citoplatino Peyrone's Chloride Blastolem cis-diamminedichloro platinum (II) Abiplatin Citosin PDD Metaplatin cis-diammine-dichloroplatinum Cisplatyl platinum, diaminedichloro-, cis- (8CI) cis-platinum II diamine dichloride Cismaplat Peyrone's Salt cisplatinum Platinoxan cis-diamminedichloroplatinum Platinex CPDD Placis Platiblastin-S Platiran (SP-4-2)-diamminedichloroplatinum cis-diamminedichloridoplatinum Neoplatin Cis-dichloroammine Platinum (II) Platinol-AQ VHA Plus Cisplatina Lederplatin CDDP
Definitions	An inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C376" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C376" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000039515
altLabel	Platamine cis-DDP Platinol- AQ CACP cis-platinous diamine dichloride Cysplatyna DDP Platistin Briplatin cis-platinum platinum diamminodichloride cis-platinum II Platiblastin Platosin Citoplatino Peyrone's Chloride Blastolem cis-diamminedichloro platinum (II) Abiplatin Citosin PDD Metaplatin cis-diammine-dichloroplatinum Cisplatyl platinum, diaminedichloro-, cis- (8CI) cis-platinum II diamine dichloride Cismaplat Peyrone's Salt cisplatinum Platinoxan cis-diamminedichloroplatinum Platinex CPDD Placis Platiblastin-S Platiran (SP-4-2)-diamminedichloroplatinum cis-diamminedichloridoplatinum Neoplatin Cis-dichloroammine Platinum (II) Platinol-AQ VHA Plus Cisplatina Lederplatin CDDP
CAS Registry	15663-27-1
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http://purl.bioontology.org/ontology/PDQ/CDR0000042923 http://purl.bioontology.org/ontology/PDQ/CDR0000041870 http://purl.bioontology.org/ontology/PDQ/CDR0000041946 http://purl.bioontology.org/ontology/PDQ/CDR0000042012 http://purl.bioontology.org/ontology/PDQ/CDR0000042011 http://purl.bioontology.org/ontology/PDQ/CDR0000041356 http://purl.bioontology.org/ontology/PDQ/CDR0000039378 http://purl.bioontology.org/ontology/PDQ/CDR0000039666 http://purl.bioontology.org/ontology/PDQ/CDR0000039122 http://purl.bioontology.org/ontology/PDQ/CDR0000039385 http://purl.bioontology.org/ontology/PDQ/CDR0000041774 http://purl.bioontology.org/ontology/PDQ/CDR0000039119 http://purl.bioontology.org/ontology/PDQ/CDR0000041280 http://purl.bioontology.org/ontology/PDQ/CDR0000037933 http://purl.bioontology.org/ontology/PDQ/CDR0000041605 http://purl.bioontology.org/ontology/PDQ/CDR0000042039 http://purl.bioontology.org/ontology/PDQ/CDR0000040995 http://purl.bioontology.org/ontology/PDQ/CDR0000037772 http://purl.bioontology.org/ontology/PDQ/CDR0000039354 http://purl.bioontology.org/ontology/PDQ/CDR0000037967 http://purl.bioontology.org/ontology/PDQ/CDR0000041232 http://purl.bioontology.org/ontology/PDQ/CDR0000041100 http://purl.bioontology.org/ontology/PDQ/CDR0000041978 http://purl.bioontology.org/ontology/PDQ/CDR0000039701 http://purl.bioontology.org/ontology/PDQ/CDR0000038054 http://purl.bioontology.org/ontology/PDQ/CDR0000041684 http://purl.bioontology.org/ontology/PDQ/CDR0000041261 http://purl.bioontology.org/ontology/PDQ/CDR0000039685 http://purl.bioontology.org/ontology/PDQ/CDR0000042610 http://purl.bioontology.org/ontology/PDQ/CDR0000039431 http://purl.bioontology.org/ontology/PDQ/CDR0000340945 http://purl.bioontology.org/ontology/PDQ/CDR0000037863 http://purl.bioontology.org/ontology/PDQ/CDR0000038856 http://purl.bioontology.org/ontology/PDQ/CDR0000042079 http://purl.bioontology.org/ontology/PDQ/CDR0000042567 http://purl.bioontology.org/ontology/PDQ/CDR0000041592 http://purl.bioontology.org/ontology/PDQ/CDR0000371705 http://purl.bioontology.org/ontology/PDQ/CDR0000042213 http://purl.bioontology.org/ontology/PDQ/CDR0000043312 http://purl.bioontology.org/ontology/PDQ/CDR0000315750 http://purl.bioontology.org/ontology/PDQ/CDR0000041127 http://purl.bioontology.org/ontology/PDQ/CDR0000041156 http://purl.bioontology.org/ontology/PDQ/CDR0000037901 http://purl.bioontology.org/ontology/PDQ/CDR0000041038 http://purl.bioontology.org/ontology/PDQ/CDR0000041218 http://purl.bioontology.org/ontology/PDQ/CDR0000040899 http://purl.bioontology.org/ontology/PDQ/CDR0000041907 http://purl.bioontology.org/ontology/PDQ/CDR0000041437 http://purl.bioontology.org/ontology/PDQ/CDR0000041243 http://purl.bioontology.org/ontology/PDQ/CDR0000043259 http://purl.bioontology.org/ontology/PDQ/CDR0000428333 http://purl.bioontology.org/ontology/PDQ/CDR0000039532 http://purl.bioontology.org/ontology/PDQ/CDR0000039774 http://purl.bioontology.org/ontology/PDQ/CDR0000041187 http://purl.bioontology.org/ontology/PDQ/CDR0000041220 http://purl.bioontology.org/ontology/PDQ/CDR0000040492 http://purl.bioontology.org/ontology/PDQ/CDR0000039626 http://purl.bioontology.org/ontology/PDQ/CDR0000039614 http://purl.bioontology.org/ontology/PDQ/CDR0000041442 http://purl.bioontology.org/ontology/PDQ/CDR0000041989 http://purl.bioontology.org/ontology/PDQ/CDR0000039465 http://purl.bioontology.org/ontology/PDQ/CDR0000038869 http://purl.bioontology.org/ontology/PDQ/CDR0000039391 http://purl.bioontology.org/ontology/PDQ/CDR0000041233 http://purl.bioontology.org/ontology/PDQ/CDR0000041454 http://purl.bioontology.org/ontology/PDQ/CDR0000041604 http://purl.bioontology.org/ontology/PDQ/CDR0000039691 http://purl.bioontology.org/ontology/PDQ/CDR0000042279 http://purl.bioontology.org/ontology/PDQ/CDR0000043556 http://purl.bioontology.org/ontology/PDQ/CDR0000040989 http://purl.bioontology.org/ontology/PDQ/CDR0000040871 http://purl.bioontology.org/ontology/PDQ/CDR0000042583 http://purl.bioontology.org/ontology/PDQ/CDR0000040155 http://purl.bioontology.org/ontology/PDQ/CDR0000041987 http://purl.bioontology.org/ontology/PDQ/CDR0000043231 http://purl.bioontology.org/ontology/PDQ/CDR0000042025 http://purl.bioontology.org/ontology/PDQ/CDR0000277242 http://purl.bioontology.org/ontology/PDQ/CDR0000040938 http://purl.bioontology.org/ontology/PDQ/CDR0000040998 http://purl.bioontology.org/ontology/PDQ/CDR0000038892 http://purl.bioontology.org/ontology/PDQ/CDR0000039528 http://purl.bioontology.org/ontology/PDQ/CDR0000038983 http://purl.bioontology.org/ontology/PDQ/CDR0000368788 http://purl.bioontology.org/ontology/PDQ/CDR0000257802 http://purl.bioontology.org/ontology/PDQ/CDR0000039612 http://purl.bioontology.org/ontology/PDQ/CDR0000040940 http://purl.bioontology.org/ontology/PDQ/CDR0000389202 http://purl.bioontology.org/ontology/PDQ/CDR0000039620 http://purl.bioontology.org/ontology/PDQ/CDR0000039613 http://purl.bioontology.org/ontology/PDQ/CDR0000042126 http://purl.bioontology.org/ontology/PDQ/CDR0000350211 http://purl.bioontology.org/ontology/PDQ/CDR0000364827 http://purl.bioontology.org/ontology/PDQ/CDR0000040926 http://purl.bioontology.org/ontology/PDQ/CDR0000355764 http://purl.bioontology.org/ontology/PDQ/CDR0000039400 http://purl.bioontology.org/ontology/PDQ/CDR0000422413 http://purl.bioontology.org/ontology/PDQ/CDR0000038124 http://purl.bioontology.org/ontology/PDQ/CDR0000042640 http://purl.bioontology.org/ontology/PDQ/CDR0000041972 http://purl.bioontology.org/ontology/PDQ/CDR0000038923 http://purl.bioontology.org/ontology/PDQ/CDR0000038277 http://purl.bioontology.org/ontology/PDQ/CDR0000040396 http://purl.bioontology.org/ontology/PDQ/CDR0000040144 http://purl.bioontology.org/ontology/PDQ/CDR0000040839 http://purl.bioontology.org/ontology/PDQ/CDR0000041288 http://purl.bioontology.org/ontology/PDQ/CDR0000430106
cui	C0699648 C1516567 C1145694 C1516571 C1516566 C1516564 C0008838 C1516569 C1516573 C1516572 C1516570 C1516562 C0722652 C1516574 C1516568 C0950644 C1516565 C1516576 C1516575 C1516563
Date last modified	2018-01-10
definition	An inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C376" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C376" NCI Thesaurus)
IND Code	8041
Legacy PDQ ID	215
LT	TRD
NCI ID	C376
notation	CDR0000039515
NSC Code	119875
ORIG STY	Drug/agent
prefLabel	cisplatin
tui	T197 T109 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/SCTSPA/387318005	SCTSPA	CUI
http://purl.bioontology.org/ontology/MESH/C044245	MESH	CUI
http://purl.bioontology.org/ontology/ATC/L01XA01	ATC	CUI
http://purl.bioontology.org/ontology/LNC/LP16079-3	LOINC	CUI
http://purl.bioontology.org/ontology/MSHFRE/D002945	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/57066004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146476	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387318005	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RXNORM/2555	RXNORM	CUI
http://purl.bioontology.org/ontology/MESH/D002945	MESH	CUI
http://purl.bioontology.org/ontology/CSP/5001-0018	CRISP	CUI
http://purl.bioontology.org/ontology/RCD/h53..	RCD	CUI
http://purl.bioontology.org/ontology/CSP/1852-8933	CRISP	CUI
http://purl.bioontology.org/ontology/RCD/Xa9RU	RCD	CUI
http://purl.bioontology.org/ontology/SNMI/C-78060	SNMI	CUI
http://purl.bioontology.org/ontology/VANDF/4018139	VANDF	CUI
http://purl.bioontology.org/ontology/SCTSPA/57066004	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDDF/002641	NDDF	CUI
http://purl.bioontology.org/ontology/LNC/MTHU060553	LOINC	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007062	NDFRT	CUI
http://purl.obolibrary.org/obo/XCO_0000398	XCO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.625.125	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C376	BERO	LOOM
http://ontology.lst.tfo.upm.es/BD2D/chemo#Cancer_Therapy_Agent_Name@@3	HENECON	LOOM
http://purl.bioontology.org/ontology/ATC/L01XA01	ATC	LOOM
http://purl.bioontology.org/ontology/LNC/LP16079-3	LOINC	LOOM
http://purl.jp/bio/4/id/200906071818370041	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0008838	OCHV	LOOM
http://ontology.lst.tfo.upm.es/SPT/follow#Cancer_Therapy_Agent_Name_rec_met@@3	HENEGEO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146476	ODAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.210.375	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3006	OCHV	LOOM
http://www.semanticweb.org/hx-jta/ontologies/thyroid_cancer_ontology#Cisplatin	TCO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C376	NCIT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C376	ROO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002945	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146476	NDFRT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387318005	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/RXNORM/2555	RXNORM	LOOM
http://purl.obolibrary.org/obo/XCO_0000398	XCO	LOOM
https://go.drugbank.com/drugs/DB00515	MDM	LOOM
http://purl.bioontology.org/ontology/MESH/D002945	MESH	LOOM
http://purl.obolibrary.org/obo/FBcv_0000576	FB-CV	LOOM
http://purl.obolibrary.org/obo/OMIT_0004262	OMIT	LOOM
http://purl.bioontology.org/ontology/CSP/5001-0018	CRISP	LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Cisplatin	PCAO	LOOM
http://neuromorpho.org/ontologies/experimentconditionH.owl#NMOOt_765	NMOBR	LOOM
http://purl.obolibrary.org/obo/HIO_0000202	HIO	LOOM
http://www.semanticweb.org/MGB/ontologies/MGBD#Cisplatin	MGBD	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78060	SNMI	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	BMONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	FB-CV	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	PECO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	ECTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	MCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	ODNAE	LOOM
http://purl.obolibrary.org/obo/CHEBI_27899	OBA	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D01.710.100	RH-MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4018139	VANDF	LOOM
http://purl.obolibrary.org/obo/EO_0007525	PEAO	LOOM
http://www.stanford.edu/~coulet/phare.owl#Cisplatin	PHARE	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015526	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/NDDF/002641	NDDF	LOOM
http://www.co-ode.org/ontologies/galen#Cisplatin	GALEN	LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_27899	NPO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060553	LOINC	LOOM
http://purl.obolibrary.org/obo/MESH_D002945	BERO	LOOM