loading...| Preferred Name |
Urea |
|
| Synonyms |
Aqua Care Carbamide Elaqua XX Lanaphilic Nutraplus UREA Urea Ureaphil Vanamide carbamide urea |
|
| Definitions |
A nitrogenous compound containing a carbonyl group attached to two amine groups with osmotic diuretic activity. In vivo, urea is formed in the liver via the urea cycle from ammonia and is the final end product of protein metabolism. Administration of urea elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain, cerebrospinal fluid and eye, into interstitial fluid and plasma, thereby decreasing pressure in those tissues and increasing urine outflow. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29531 |
|
| ALT_DEFINITION |
A substance formed by the breakdown of protein in the liver. The kidneys filter carbamide out of the blood and into the urine. Carbamide can also be made in the laboratory. A topical form of carbamide is being studied in the treatment of hand-foot syndrome (pain, swelling, numbness, tingling, or redness of the hands or feet that may occur as a side effect of certain anticancer drugs). |
|
| CAS_Registry |
57-13-6 |
|
| CHEBI_ID |
CHEBI:16199 |
|
| Chemical_Formula |
CH4N2O |
|
| code |
C29531 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A nitrogenous compound containing a carbonyl group attached to two amine groups with osmotic diuretic activity. In vivo, urea is formed in the liver via the urea cycle from ammonia and is the final end product of protein metabolism. Administration of urea elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain, cerebrospinal fluid and eye, into interstitial fluid and plasma, thereby decreasing pressure in those tissues and increasing urine outflow. |
|
| FDA_UNII_Code |
8W8T17847W |
|
| FULL_SYN |
Aqua Care Carbamide Elaqua XX Lanaphilic Nutraplus UREA Urea Ureaphil Vanamide carbamide urea |
|
| label |
Urea |
|
| Legacy Concept Name |
Carbamide |
|
| NCI_Drug_Dictionary_ID |
40286 |
|
| NSC Number |
34375 |
|
| PDQ_Closed_Trial_Search_ID |
40286 |
|
| PDQ_Open_Trial_Search_ID |
40286 |
|
| Preferred_Name |
Urea |
|
| prefixIRI |
Thesaurus:C29531 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0041942 |
|
| subClassOf |