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National Cancer Institute Thesaurus
| Preferred Name | Mitomycin | |
| Synonyms |
Mitomycin-C Mitomycin-X Mitomycine C [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione Mitomycin C MITOMYCIN C (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione Ametycine Jelmyto MITO MITO-C MITOMYCIN Mito-C Mito-Medac Mitocin Mitocin-C Mitolem Mitomycin Mitosol Mitozytrex Mutamycin Mutamycine NCI-C04706 |
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| Definitions |
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1820 |
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| Accepted_Therapeutic_Use_For |
Gastric Carcinoma Pancreatic Adenocarcinoma
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| CAS_Registry |
50-07-7
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| CHEBI_ID |
CHEBI:27504
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| Chemical_Formula |
C15H18N4O5
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| code |
C1820
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC HemOnc
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|
| DEFINITION |
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)
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| Display_Name |
Mitomycin
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| FDA_UNII_Code |
50SG953SK6
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| FULL_SYN |
Mitomycin-C Mitomycin-X Mitomycine C [1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione Mitomycin C MITOMYCIN C (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione Ametycine Jelmyto MITO MITO-C MITOMYCIN Mito-C Mito-Medac Mitocin Mitocin-C Mitolem Mitomycin Mitosol Mitozytrex Mutamycin Mutamycine NCI-C04706
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| Is_Value_For_GDC_Property | ||
| label |
Mitomycin
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|
| Legacy Concept Name |
Mitomycin_C
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|
| Maps_To |
Mitomycin
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| NCI_Drug_Dictionary_ID |
42674
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| NSC Number |
26980
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|
| PDQ_Closed_Trial_Search_ID |
42674
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|
| PDQ_Open_Trial_Search_ID |
42674
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| Preferred_Name |
Mitomycin
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|
| prefixIRI |
Thesaurus:C1820
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0002475
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| subClassOf |
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