loading...| Preferred Name |
Mitomycin Antineoplastic Antibiotic |
|
| Synonyms |
Mitomycin Antineoplastic Antibiotic mitomycin |
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| Definitions |
Any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C663 |
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| Accepted_Therapeutic_Use_For |
Anal cancer; Bladder cancer; Breast cancer; Bronchogenic cancer; Cervical cancer; Colorectal cancer; Esophageal cancer; Gastric carcinoma; Head and neck cancer; Liver cancer; Pancreatic carcinoma; Pterygia |
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called antitumor antibiotics. |
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| CHEBI_ID |
CHEBI:25357 |
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| code |
C663 |
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| DEFINITION |
Any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis. |
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| FULL_SYN |
Mitomycin Antineoplastic Antibiotic mitomycin |
|
| label |
Mitomycin Antineoplastic Antibiotic |
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| Legacy Concept Name |
Mitomycin_Antibiotic |
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| Preferred_Name |
Mitomycin Antineoplastic Antibiotic |
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| prefixIRI |
Thesaurus:C663 |
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| Semantic_Type |
Chemical Viewed Functionally |
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| UMLS_CUI |
C0026254 |
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| subClassOf |