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Microbial Conditions Ontology
| Preferred Name | EC 5.99.1.2 (DNA topoisomerase) inhibitor | |
| Synonyms |
topoisomerase I inhibitors DNA topoisomerase inhibitor EC 5.99.1.2 (DNA topoisomerase) inhibitors topoisomerase I (EC 5.99.1.2) inhibitors topoisomerase I (EC 5.99.1.2) inhibitor EC 5.99.1.2 (topoisomerase I) inhibitor DNA topoisomerase inhibitors type I DNA topoisomerase inhibitor topoisomerase I inhibitor EC 5.99.1.2 (topoisomerase I) inhibitors EC 5.99.1.2 inhibitors type I DNA topoisomerase inhibitors EC 5.99.1.2 inhibitor |
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| Definitions |
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_50276 |
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| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
topoisomerase I inhibitors DNA topoisomerase inhibitor EC 5.99.1.2 (DNA topoisomerase) inhibitors topoisomerase I (EC 5.99.1.2) inhibitors topoisomerase I (EC 5.99.1.2) inhibitor EC 5.99.1.2 (topoisomerase I) inhibitor DNA topoisomerase inhibitors type I DNA topoisomerase inhibitor topoisomerase I inhibitor EC 5.99.1.2 (topoisomerase I) inhibitors EC 5.99.1.2 inhibitors type I DNA topoisomerase inhibitors EC 5.99.1.2 inhibitor
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| id |
CHEBI:50276
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| in_subset | ||
| label |
EC 5.99.1.2 (DNA topoisomerase) inhibitor
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| notation |
CHEBI:50276
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| prefLabel |
EC 5.99.1.2 (DNA topoisomerase) inhibitor
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| textual definition |
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
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