loading...| Preferred Name | MyD88 cascade initiated on plasma membrane | |
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| Definitions |
Edited: Shamovsky, V, 2011-08-12 Reviewed: Gillespie, ME, 2011-02-10 Reviewed: Li, L, 2011-08-04 Authored: Shamovsky, V, 2010-10-06 Mammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of TLR3, can initiate downstream signaling trough MyD88. In the MyD88 - dependent pathway, once the adaptor is bound to TLR it leads to recruitment of IL1 receptor associated kinase family â IRAK which is followed by activation of tumour necrosis factor receptor-associated factor 6 (TRAF6) . TRAF6 is an ubiquitin E3 ligase which in turn induces TGF-beta activating kinase 1 (TAK1) auto phosphorylation. Once activated TAK1 can ultimately mediate the induction of the transcription factor NF-kB or the mitogen-activated protein kinases (MAPK), such as JNK, p38 and ERK. This results in the translocation of the activated NF-kB and MAPKs to the nucleus and the initiation of appropriate gene transcription leading to the production of many proinflammatory cytokines and antimicrobial peptides. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022356 |
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| comment |
Edited: Shamovsky, V, 2011-08-12 Reviewed: Gillespie, ME, 2011-02-10 Reviewed: Li, L, 2011-08-04 Authored: Shamovsky, V, 2010-10-06 Mammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of TLR3, can initiate downstream signaling trough MyD88. In the MyD88 - dependent pathway, once the adaptor is bound to TLR it leads to recruitment of IL1 receptor associated kinase family â IRAK which is followed by activation of tumour necrosis factor receptor-associated factor 6 (TRAF6) . TRAF6 is an ubiquitin E3 ligase which in turn induces TGF-beta activating kinase 1 (TAK1) auto phosphorylation. Once activated TAK1 can ultimately mediate the induction of the transcription factor NF-kB or the mitogen-activated protein kinases (MAPK), such as JNK, p38 and ERK. This results in the translocation of the activated NF-kB and MAPKs to the nucleus and the initiation of appropriate gene transcription leading to the production of many proinflammatory cytokines and antimicrobial peptides. |
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| definition source |
Pubmed10435584 Reactome, http://www.reactome.org Pubmed15728506 Pubmed9430229 Pubmed16239509 |
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| label |
MyD88 cascade initiated on plasma membrane |
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| prefixIRI |
HINO:0022356 |
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| prefLabel |
MyD88 cascade initiated on plasma membrane |
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| seeAlso |
ReactomeREACT_27215 Reactome Database ID Release 43975871 GENE ONTOLOGYGO:0002755 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0009354 http://purl.obolibrary.org/obo/HINO_0009382 http://purl.obolibrary.org/obo/HINO_0009384 http://purl.obolibrary.org/obo/HINO_0009381 http://purl.obolibrary.org/obo/HINO_0009386 http://purl.obolibrary.org/obo/HINO_0015703 http://purl.obolibrary.org/obo/HINO_0015704 http://purl.obolibrary.org/obo/HINO_0022346 http://purl.obolibrary.org/obo/HINO_0009331 http://purl.obolibrary.org/obo/HINO_0022354 http://purl.obolibrary.org/obo/HINO_0009375 http://purl.obolibrary.org/obo/HINO_0009374 http://purl.obolibrary.org/obo/HINO_0009377 http://purl.obolibrary.org/obo/HINO_0009379 |