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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0009378
http://purl.obolibrary.org/obo/HINO_0009378
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| Preferred Name | MyD88 oligomerization within the complex of activated TLR:MyD88 |
| Definitions |
Edited: Shamovsky, V, 2011-08-12
Structural analysis of MyD88:IRAK4 and MyD88:IRAK4:IRAK2 suggested that upon MyD88 recruitment to an activated dimerized TLR the MyD88 death domains clustering induces the formation of Mydosome, a large oligomeric signaling platform (Motshwene PG et al 2009, Lin SC et al 2010). Assembly of these Myddosome complexes brings the kinase domains of IRAKs into proximity for phosphorylation and activation. The oligomer complex stoichiometry was reported as 7:4 and 8:4 for MyD88:IRAK4 (Motshwene PG et al 2009), and 6:4:4 in the complex of MyD88:IRAK4:IRAK2(Lin SC et al 2010).
has a Stoichiometric coefficient of 4
Reviewed: Gillespie, ME, 2011-02-10
Reviewed: Li, L, 2011-08-04
Authored: Shamovsky, V, 2010-10-06
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
MyD88 oligomerization within the complex of activated TLR:MyD88
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| comment |
Edited: Shamovsky, V, 2011-08-12
Structural analysis of MyD88:IRAK4 and MyD88:IRAK4:IRAK2 suggested that upon MyD88 recruitment to an activated dimerized TLR the MyD88 death domains clustering induces the formation of Mydosome, a large oligomeric signaling platform (Motshwene PG et al 2009, Lin SC et al 2010). Assembly of these Myddosome complexes brings the kinase domains of IRAKs into proximity for phosphorylation and activation. The oligomer complex stoichiometry was reported as 7:4 and 8:4 for MyD88:IRAK4 (Motshwene PG et al 2009), and 6:4:4 in the complex of MyD88:IRAK4:IRAK2(Lin SC et al 2010).
has a Stoichiometric coefficient of 4
Reviewed: Gillespie, ME, 2011-02-10
Reviewed: Li, L, 2011-08-04
Authored: Shamovsky, V, 2010-10-06
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| prefLabel |
MyD88 oligomerization within the complex of activated TLR:MyD88
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| definition source |
Pubmed20485341
Reactome, http://www.reactome.org
Pubmed19592493
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| prefixIRI |
HINO:0009378
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| seeAlso |
ReactomeREACT_27210
Reactome Database ID Release 43975880
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| has output |
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