loading...| Preferred Name | TAK1 activates NFkB by phosphorylation and activation of IKKs complex | |
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| Definitions |
Edited: Shamovsky, V, 2011-08-12 Reviewed: Fitzgerald, Katherine A, 2012-11-13 Reviewed: Gillespie, ME, 2010-02-27 Reviewed: Napetschnig, Johanna, 2012-11-16 NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression. Authored: Shamovsky, V, 2009-12-16 |
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http://purl.obolibrary.org/obo/HINO_0015704 |
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Edited: Shamovsky, V, 2011-08-12 Reviewed: Fitzgerald, Katherine A, 2012-11-13 Reviewed: Gillespie, ME, 2010-02-27 Reviewed: Napetschnig, Johanna, 2012-11-16 NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression. Authored: Shamovsky, V, 2009-12-16 |
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| definition source |
Pubmed11460167 Reactome, http://www.reactome.org Pubmed15837794 Pubmed15145317 |
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TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
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HINO:0015704 |
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TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
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ReactomeREACT_21281 Reactome Database ID Release 43445989 GENE ONTOLOGYGO:0051092 |
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http://purl.obolibrary.org/obo/HINO_0026733 |