loading...| Preferred Name | First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR | |
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| Definitions |
Edited: Shamovsky, V, 2011-08-12 has a Stoichiometric coefficient of 4 Reviewed: Gillespie, ME, 2011-02-10 Reviewed: Li, L, 2011-08-04 Authored: Shamovsky, V, 2010-10-06 First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0009381 |
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Edited: Shamovsky, V, 2011-08-12 has a Stoichiometric coefficient of 4 Reviewed: Gillespie, ME, 2011-02-10 Reviewed: Li, L, 2011-08-04 Authored: Shamovsky, V, 2010-10-06 First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1. |
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| definition source |
Reactome, http://www.reactome.org Pubmed14625308 Pubmed11960013 |
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| label |
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR |
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| prefixIRI |
HINO:0009381 |
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| prefLabel |
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR |
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| seeAlso |
Reactome Database ID Release 43975878 ReactomeREACT_27228 |
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