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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0009375
http://purl.obolibrary.org/obo/HINO_0009375
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| Preferred Name | IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor |
| Definitions |
Edited: Shamovsky, V, 2011-08-12
has a Stoichiometric coefficient of 4
Reviewed: Gillespie, ME, 2011-02-10
Reviewed: Li, L, 2011-08-04
IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002].
Authored: Shamovsky, V, 2010-10-06
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor
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| comment |
Edited: Shamovsky, V, 2011-08-12
has a Stoichiometric coefficient of 4
Reviewed: Gillespie, ME, 2011-02-10
Reviewed: Li, L, 2011-08-04
IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002].
Authored: Shamovsky, V, 2010-10-06
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| prefLabel |
IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor
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| definition source |
Pubmed12297423
Reactome, http://www.reactome.org
Pubmed11960013
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| prefixIRI |
HINO:0009375
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| seeAlso |
Reactome Database ID Release 43975873
ReactomeREACT_27293
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| subClassOf | |
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| has input | |
| has output |
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