loading...| Preferred Name |
Spry regulation of FGF signaling |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Sprouty was initially characterized as a negative regulator of FGFR signaling in Drosophila. Human cells contain four genes encoding Sprouty proteins, of which Spry2 is the best studied and most widely expressed. Spry proteins modulate the duration and extent of signaling through the MAPK cascade after FGF stimulation, although the mechanism appears to depend on the particular biological context. Some studies have suggested that Sprouty binds to GRB2 and interferes with the recruitment of GRB2-SOS1 to the receptor, while others have shown that Sprouty interferes with the MAPK cascade at the level of RAF activation. In addition to modulating the MAPK pathway in response to FGF stimulation, Sprouty itself appears to be subject to complex post-translational modification that regulates its activity and stability. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016297 |
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| comment |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Sprouty was initially characterized as a negative regulator of FGFR signaling in Drosophila. Human cells contain four genes encoding Sprouty proteins, of which Spry2 is the best studied and most widely expressed. Spry proteins modulate the duration and extent of signaling through the MAPK cascade after FGF stimulation, although the mechanism appears to depend on the particular biological context. Some studies have suggested that Sprouty binds to GRB2 and interferes with the recruitment of GRB2-SOS1 to the receptor, while others have shown that Sprouty interferes with the MAPK cascade at the level of RAF activation. In addition to modulating the MAPK pathway in response to FGF stimulation, Sprouty itself appears to be subject to complex post-translational modification that regulates its activity and stability. |
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| definition source |
Pubmed9458049 Pubmed19570949 Reactome, http://www.reactome.org Pubmed16893902 Pubmed19690147 |
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Spry regulation of FGF signaling |
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| prefixIRI |
HINO:0016297 |
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| prefLabel |
Spry regulation of FGF signaling |
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| seeAlso |
ReactomeREACT_111080 Reactome Database ID Release 431295596 |
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http://purl.obolibrary.org/obo/HINO_0009054 http://purl.obolibrary.org/obo/HINO_0009057 http://purl.obolibrary.org/obo/HINO_0009055 http://purl.obolibrary.org/obo/HINO_0009056 http://purl.obolibrary.org/obo/HINO_0009053 http://purl.obolibrary.org/obo/HINO_0009052 http://purl.obolibrary.org/obo/HINO_0009058 http://purl.obolibrary.org/obo/HINO_0009020 http://purl.obolibrary.org/obo/HINO_0009024 |