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SHP2 dephosphorylates SPRY2 |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 SHP2 may exert its positive effects on MAPK activation in response to FGF stimulation by catalyzing the dephosphorylation of tyrosine resides on SPRY2. This dephosphorylation promotes dissociation of the GRB2/SPRY2 complex and as a consequence stimulates GRB2 association with the activated receptor, leading to sustained MAPK signaling. Authored: Rothfels, K, 2011-08-15 |
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http://purl.obolibrary.org/obo/HINO_0009058 |
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Reviewed: Gotoh, N, 2011-08-26 SHP2 may exert its positive effects on MAPK activation in response to FGF stimulation by catalyzing the dephosphorylation of tyrosine resides on SPRY2. This dephosphorylation promotes dissociation of the GRB2/SPRY2 complex and as a consequence stimulates GRB2 association with the activated receptor, leading to sustained MAPK signaling. Authored: Rothfels, K, 2011-08-15 |
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| definition source |
Reactome, http://www.reactome.org Pubmed17993263 Pubmed15031289 |
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SHP2 dephosphorylates SPRY2 |
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| prefixIRI |
HINO:0009058 |
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SHP2 dephosphorylates SPRY2 |
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ReactomeREACT_111157 Reactome Database ID Release 431549564 EC Number: 3.1.3.48 |
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