SRC phosphorylates SPRY2 on Y55 and Y227

has a Stoichiometric coefficient of 2 Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Sprouty 2 protein is phosphorylated on tyrosine residue 55. The ability of SRC kinase to catalyze this reaction has been demonstrated with purified proteins in vitro (Li et al. 2004) and in cultured cells with studies of the effects of SRC-family pharmacological inhibitors and of dominant-negative mutant SRC proteins (Mason et al. 2004). SRC kinase also phosphorylates numerous tyrosine residues in the C terminal region of SPRY2 including Y227, in response to FGF but not EGF stimulation.

http://purl.obolibrary.org/obo/HINO_0009025

has a Stoichiometric coefficient of 2

Reviewed: Gotoh, N, 2011-08-26

Authored: Rothfels, K, 2011-08-15

Sprouty 2 protein is phosphorylated on tyrosine residue 55. The ability of SRC kinase to catalyze this reaction has been demonstrated with purified proteins in vitro (Li et al. 2004) and in cultured cells with studies of the effects of SRC-family pharmacological inhibitors and of dominant-negative mutant SRC proteins (Mason et al. 2004). SRC kinase also phosphorylates numerous tyrosine residues in the C terminal region of SPRY2 including Y227, in response to FGF but not EGF stimulation.

Pubmed15004239

Reactome, http://www.reactome.org

Pubmed15637081

Pubmed15564375

http://purl.obolibrary.org/obo/HINO_0017253

http://purl.obolibrary.org/obo/CHEBI_15422

http://purl.obolibrary.org/obo/HINO_0017264

http://purl.obolibrary.org/obo/CHEBI_16761

SRC phosphorylates SPRY2 on Y55 and Y227

HINO:0009025

SRC phosphorylates SPRY2 on Y55 and Y227

ReactomeREACT_111096

EC Number: 2.7.10

Reactome Database ID Release 431295609

http://purl.obolibrary.org/obo/INO_0000040