loading...| Preferred Name | SPRY2 binds CBL | |
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Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 The N terminal TKB domain of CBL binds to the phospho-tyrosine 55 of SPRY2, targeting SPRY2 for degradation by the 26S proteasome. Y55 is also a binding site for PP2A, which dephosphorylates numerous serine and threonine residues on SPRY2, allowing a conformational change that may promote a SPRY2:GRB2 interaction and limit the extent of MAPK activation following FGF stimulation. |
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http://purl.obolibrary.org/obo/HINO_0009052 |
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Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 The N terminal TKB domain of CBL binds to the phospho-tyrosine 55 of SPRY2, targeting SPRY2 for degradation by the 26S proteasome. Y55 is also a binding site for PP2A, which dephosphorylates numerous serine and threonine residues on SPRY2, allowing a conformational change that may promote a SPRY2:GRB2 interaction and limit the extent of MAPK activation following FGF stimulation. |
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Pubmed12815057 Reactome, http://www.reactome.org Pubmed12593796 Pubmed11053437 |
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SPRY2 binds CBL |
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HINO:0009052 |
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SPRY2 binds CBL |
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Reactome Database ID Release 431295622 ReactomeREACT_111241 |
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