loading...| Preferred Name |
FRS2-mediated cascade |
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| Synonyms |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 Authored: de Bono, B, 2007-01-10 10:27:18 Edited: Jupe, S, 2010-02-03 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 The FRS family of scaffolding adaptor proteins has two members, FRS2alpha and FRS2beta (also known as FRS3 or SNT-2). Activation of FGFR tyrosine kinase allows FRS2 proteins to become phosphorylated on tyrosine residues and then bind to the adaptor GRB2 and the tyrosine phosphatase SHP2. Subsequently, SHP2 activates the RAS-MAP kinase pathway and GRB2 activates the RAS-MAP kinase , PI-3-kinase and ubiquitinations/degradation pathways by binding to SOS, GAB1 and CBL, respectively, via the SH3 domains of GRB2. FRS2alpha acts as a central mediator in FGF signaling mainly because it induces sustained levels of activation of ERK with ubiquitous expression.<br><br><br> |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016040 |
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| comment |
Reviewed: Gotoh, N, 2011-08-26 Authored: de Bono, B, 2007-01-10 10:27:18 Edited: Jupe, S, 2010-02-03 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 The FRS family of scaffolding adaptor proteins has two members, FRS2alpha and FRS2beta (also known as FRS3 or SNT-2). Activation of FGFR tyrosine kinase allows FRS2 proteins to become phosphorylated on tyrosine residues and then bind to the adaptor GRB2 and the tyrosine phosphatase SHP2. Subsequently, SHP2 activates the RAS-MAP kinase pathway and GRB2 activates the RAS-MAP kinase , PI-3-kinase and ubiquitinations/degradation pathways by binding to SOS, GAB1 and CBL, respectively, via the SH3 domains of GRB2. FRS2alpha acts as a central mediator in FGF signaling mainly because it induces sustained levels of activation of ERK with ubiquitous expression. |
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| definition source |
Pubmed16682955 Reactome, http://www.reactome.org Pubmed11447289 Pubmed18452557 Pubmed15863030 Pubmed9182757 Pubmed10377388 |
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| label |
FRS2-mediated cascade |
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| located_in | ||
| prefixIRI |
HINO:0016040 |
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| prefLabel |
FRS2-mediated cascade |
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| seeAlso |
ReactomeREACT_21247 Reactome Database ID Release 43190345 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0008845 http://purl.obolibrary.org/obo/HINO_0008833 http://purl.obolibrary.org/obo/HINO_0008834 http://purl.obolibrary.org/obo/HINO_0008839 http://purl.obolibrary.org/obo/HINO_0008835 http://purl.obolibrary.org/obo/HINO_0008836 http://purl.obolibrary.org/obo/HINO_0008838 |