loading...| Preferred Name |
GRB2:SOS1 binds to p-FRS2:activated FGFR |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by means of the SH3 domain of GRB2, leading to RAS-MAP kinase activation. The FRS2:GRB2-mediated pathway plays a minor role in the activation of RAS-MAP kinase pathway compared to that mediated by FRS2:SHP2. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008837 |
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| comment |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by means of the SH3 domain of GRB2, leading to RAS-MAP kinase activation. The FRS2:GRB2-mediated pathway plays a minor role in the activation of RAS-MAP kinase pathway compared to that mediated by FRS2:SHP2. |
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| definition source |
Pubmed8780727 Pubmed11353842 Reactome, http://www.reactome.org Pubmed11447289 Pubmed7559490 Pubmed9182757 |
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| label |
GRB2:SOS1 binds to p-FRS2:activated FGFR |
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| prefixIRI |
HINO:0008837 |
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| prefLabel |
GRB2:SOS1 binds to p-FRS2:activated FGFR |
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| seeAlso |
ReactomeREACT_111204 Reactome Database ID Release 431268255 |
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