loading...| Preferred Name |
Activated FGFR binds FRS2alpha |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 FRS2alpha is broadly expressed in adult and fetal tissues. Membrane-bound FRS2alpha interacts with FGFR as a first step in the phosphorylation of this docking protein. The juxtamembrane binding site for FRS2alpha does not contain tyrosine, so binding may be independent of receptor activation and/or constitutive. Activation of the FGFR receptor is required for FRS2alpha phosphorylation and subsequent recruitment of downstream effectors. Authored: Rothfels, K, 2011-08-15 |
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http://purl.obolibrary.org/obo/HINO_0008845 |
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Reviewed: Gotoh, N, 2011-08-26 FRS2alpha is broadly expressed in adult and fetal tissues. Membrane-bound FRS2alpha interacts with FGFR as a first step in the phosphorylation of this docking protein. The juxtamembrane binding site for FRS2alpha does not contain tyrosine, so binding may be independent of receptor activation and/or constitutive. Activation of the FGFR receptor is required for FRS2alpha phosphorylation and subsequent recruitment of downstream effectors. Authored: Rothfels, K, 2011-08-15 |
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| definition source |
Pubmed9660748 Reactome, http://www.reactome.org Pubmed10629055 Pubmed18373495 |
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Activated FGFR binds FRS2alpha |
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| prefixIRI |
HINO:0008845 |
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| prefLabel |
Activated FGFR binds FRS2alpha |
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| seeAlso |
ReactomeREACT_111055 Reactome Database ID Release 431268220 |
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