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Environmental conditions, treatments and exposures ontology
| Preferred Name | EC 5.99.1.2 (DNA topoisomerase) inhibitor | |
| Synonyms |
topoisomerase I (EC 5.99.1.2) inhibitor DNA topoisomerase inhibitor DNA topoisomerase inhibitors EC 5.99.1.2 (topoisomerase I) inhibitor EC 5.99.1.2 (topoisomerase I) inhibitors topoisomerase I inhibitor EC 5.99.1.2 inhibitor type I DNA topoisomerase inhibitor type I DNA topoisomerase inhibitors EC 5.99.1.2 (DNA topoisomerase) inhibitors topoisomerase I (EC 5.99.1.2) inhibitors topoisomerase I inhibitors EC 5.99.1.2 inhibitors |
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| Definitions |
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_50276 |
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chebi_ontology
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topoisomerase I (EC 5.99.1.2) inhibitor DNA topoisomerase inhibitor DNA topoisomerase inhibitors EC 5.99.1.2 (topoisomerase I) inhibitor EC 5.99.1.2 (topoisomerase I) inhibitors topoisomerase I inhibitor EC 5.99.1.2 inhibitor type I DNA topoisomerase inhibitor type I DNA topoisomerase inhibitors EC 5.99.1.2 (DNA topoisomerase) inhibitors topoisomerase I (EC 5.99.1.2) inhibitors topoisomerase I inhibitors EC 5.99.1.2 inhibitors
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CHEBI:50276
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| label |
EC 5.99.1.2 (DNA topoisomerase) inhibitor
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| notation |
CHEBI:50276
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EC 5.99.1.2 (DNA topoisomerase) inhibitor
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| textual definition |
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
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