Link to this page
BioModels Ontology
Last uploaded:
April 3, 2012
Jump to:
| Preferred Name | topoisomerase I inhibitor | |
| Synonyms |
|
|
| Definitions |
An inhibitor of bacterial enzymes of the DNA topoisomerases, Type I class that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_50276 |
|
| alternative term |
topoisomerase I inhibitors
|
|
| definition |
An inhibitor of bacterial enzymes of the DNA topoisomerases, Type I class that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
|
|
| label |
topoisomerase I inhibitor
|
|
| prefixIRI |
CHEBI:50276
|
|
| prefLabel |
topoisomerase I inhibitor
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping