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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Mitomycin | |
| Synonyms |
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| Definitions |
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1820 |
|
| Accepted_Therapeutic_Use_For |
Gastric Carcinoma Pancreatic Adenocarcinoma
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| CAS_Registry |
50-07-7
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| CHEBI_ID |
CHEBI:27504
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| Chemical_Formula |
C15H18N4O5
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|
| code |
C1820
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)
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| Display_Name |
Mitomycin
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| FDA_UNII_Code |
50SG953SK6
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Mitomycin
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|
| Legacy Concept Name |
Mitomycin_C
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|
| Maps_To |
Mitomycin
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|
| NCI_Drug_Dictionary_ID |
42674
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|
| NSC Number |
26980
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|
| PDQ_Closed_Trial_Search_ID |
42674
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| PDQ_Open_Trial_Search_ID |
42674
|
|
| Preferred_Name |
Mitomycin
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|
| prefixIRI |
NCIT:C1820
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|
| prefLabel |
Mitomycin
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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|
| UMLS_CUI |
C0002475
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| subClassOf |
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