Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Mitomycin Antineoplastic Antibiotic
Synonyms
Definitions

Any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis.
ID

http://purl.obolibrary.org/obo/NCIT_C663
Accepted_Therapeutic_Use_For

Anal cancer; Bladder cancer; Breast cancer; Bronchogenic cancer; Cervical cancer; Colorectal cancer; Esophageal cancer; Gastric carcinoma; Head and neck cancer; Liver cancer; Pancreatic carcinoma; Pterygia
ALT_DEFINITION

An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
CHEBI_ID

CHEBI:25357
code

C663
definition

Any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis.
label

Mitomycin Antineoplastic Antibiotic
Legacy Concept Name

Mitomycin_Antibiotic
Preferred_Name

Mitomycin Antineoplastic Antibiotic
prefixIRI

NCIT:C663
prefLabel

Mitomycin Antineoplastic Antibiotic
Semantic_Type

Chemical Viewed Functionally
UMLS_CUI

C0026254
subClassOf

http://purl.obolibrary.org/obo/NCIT_C292

http://purl.obolibrary.org/obo/NCIT_C259
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