loading...| Preferred Name |
Diltiazem |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassbae370ac_6599_4153_844f_985afb86dce0 |
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| Chinese |
地尔硫卓 |
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| label |
Diltiazem |
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| MESH_Definition |
A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions. |
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| NCIt_Definition |
A benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem blocks voltage-sensitive calcium channels in the blood vessels, by inhibiting the ion-control gating mechanisms, thereby preventing calcium levels increase by other revenues. Alternatively, it has been suggested that this agent also interferes with the release of calcium from the sarcoplasmic reticulum and inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The overall low calcium levels leads to dilatation of the main coronary and systemic arteries and decreasing myocardial contractility, decreased peripheral arterial resistance, improved oxygen delivery to the myocardial tissue, and decreased cardiac output. |
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| prefLabel |
Diltiazem |
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| Synonyms |
15-Benzothiazepin-4(5H)-one 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-23-dihydro-2-(4-methoxyphenyl)- (2S-cis)- Diltiazem (substance) (2S3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2345-tetrahydrobenzo[b][14]thiazepin-3-yl acetate Acetic acid (2S3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2345-tetrahydro-benzo[b][14]thiazepin-3-yl ester (+)-cis-5-[2-(dimethylamino)ethyl]-23-dihydro-3-hydroxy-2-(p-methoxyphenyl)-15-benzothiazepin-4(5H)-one acetate ester diltiazem (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-23-dihydro-2-(4-methoxyphenyl)-15-benzothiazepin-4(5H)-one Diltiazemum d-cis-diltiazem Product containing diltiazem (medicinal product) Diltiazem-containing product |
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