loading...| Preferred Name |
Letrozole |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass731d61fb_cd1b_4ae6_b7cc_326a9444e994 |
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| Chinese |
来曲唑 |
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| label |
Letrozole |
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| MESH_Definition |
A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. It is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women. |
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| NCIt_Definition |
A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. |
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| prefLabel |
Letrozole |
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| Synonyms |
LTZ Product containing letrozole (medicinal product) Letrozole-containing product 44-(1H-124triazol-1-ylmethylene)dibenzonitrile letrozole 44-(1H-124-triazol-1-yl-methylene)-bis(benzonitrile) Femara Benzonitrile 44-(1H-124-triazol-1-ylmethylene)bis- Fémara CGS 20267 Letrozole (substance) Femara® CGS-20267 112809-51-5 CGS20267 Letrozol 719345 |
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