loading...| Preferred Name |
Felbamate |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass63a5effa_1582_405a_a09e_bd2f008cd786 |
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| Chinese |
非氨酯 |
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| label |
Felbamate |
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| MESH_Definition |
A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY. |
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| NCIt_Definition |
A propanediol compound with anticonvulsant and antiepileptic properties. Although the exact mechanism of action is unknown, Felbamate may be an antagonist at the strychnine-insensitive glycine-recognition site of the N-methyl-D-aspartate (NMDA) receptor-ionophore complex, thereby blocking the effects of the excitatory amino acids, suppressing neuronal firing, and preventing seizure activity. Felbamate also has weak inhibitory effects on gamma-aminobutyric acid (GABA) receptor binding sites which may contribute to its inhibitory effect on neuronal excitatory. |
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| prefLabel |
Felbamate |
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| Synonyms |
Felbatol FELBAMATE Felbamate 2 Phenyl 13 propanediol dicarbamate Felbamato Product containing felbamate (medicinal product) carbamic acid 2-phenyltrimethylene ester 2-Phenyl-13-propanediol dicarbamate 13-Propanediol 2-phenyl- dicarbamate Felbamate-containing product Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester 2-Phenyl-13-propanediol Dicarbamate (3-Carbamoyloxy-2-phenyl-propyl) carbamate Carbamic Acid 2-phenyltrimethylene Ester Felbamatum felbamate 2-phenyl-13-propanediol dicarbamate Felbamate (substance) |
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| subClassOf |