loading...| Preferred Name |
endocardial cushion |
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| Synonyms |
atrioventricular canal cushion endocardial cushions cardiac cushion endocardial cushion tissue atrioventricular cushion AV cushion |
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| Definitions |
The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0002062 |
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| comment |
GO graph seems to suggest this is an endothelium. WP: The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial to mesenchymal transformation, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards to interior of the heart tube). Latest (2010-06-01) new def suggested for GO, added above. Note that EHDAA2 has a more detailed model which we may later adopt. JB: Patterning makes the cushions lay down connective tissue in three domains that force out the local endothelial lining and so the leaflets form |
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| axiom_lost_from_external_ontology |
relationship loss: develops_from endocardial ring (TAO:0005072)[TAO] |
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| database_cross_reference |
VHOG:0000932 MESH:D054089 ZFA:0001317 Wikipedia:Atrioventricular_cushions EHDAA2:0004028 EMAPA:16696 TAO:0001317 XAO:0004189 EHDAA2:0000434 EHDAA:2586 FMA:70302 MA:0000078 |
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| definition |
The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. |
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| depiction |
http://upload.wikimedia.org/wikipedia/commons/c/c7/Gray465.png |
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| develops_from | ||
| external_definition |
Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves.[TAO] |
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| has_exact_synonym |
cardiac cushion endocardial cushion tissue atrioventricular cushion AV cushion |
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| has_obo_namespace |
uberon |
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| has_related_synonym |
atrioventricular canal cushion endocardial cushions |
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| homology_notes |
(Cardiac valve formation in vertebrates) In response to a myocardial signal, endocardial cells at chamber boundaries take on a mesenchymal character, delaminate and migrate into the cardiac jelly. There, they form an endocardial cushion that is later remodelled into a valve.[well established][VHOG] |
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| id |
UBERON:0002062 |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#vertebrate_core |
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| label |
endocardial cushion |
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| notation |
UBERON:0002062 |
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| part_of |
http://purl.obolibrary.org/obo/UBERON_0000922 |
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| prefLabel |
endocardial cushion |
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| treeView |
http://purl.obolibrary.org/obo/UBERON_0000922 http://purl.obolibrary.org/obo/UBERON_0002165 |
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| subClassOf |
http://purl.obolibrary.org/obo/UBERON_0002050 http://purl.obolibrary.org/obo/UBERON_0009751 http://purl.obolibrary.org/obo/UBERON_0014387 |