Preferred Name |
benazepril |
|
Synonyms |
[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid Benazepril benazeprilum 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))- benazepril |
|
Definitions |
A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_3011 |
|
charge |
0 |
|
database_cross_reference |
KEGG:D07499 Drug_Central:299 PMID:25738503 HMDB:HMDB0014682 CAS:86541-75-5 Reaxys:4302258 PMID:25784709 Patent:US4410520 Patent:EP72352 LINCS:LSM-5609 PMID:25224804 MetaCyc:CPD-15329 DrugBank:DB00542 Wikipedia:Benazepril PMID:25912588 KEGG:C06843 |
|
formula |
C24H28N2O5 |
|
has functional parent | ||
has role | ||
has_exact_synonym |
[(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid Benazepril |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
benazeprilum 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))- benazepril |
|
has_RxCUI |
18867 |
|
id |
CHEBI:3011 |
|
in_subset | ||
inchi |
InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1 |
|
inchikey |
XPCFTKFZXHTYIP-PMACEKPBSA-N |
|
is bearer of | ||
is conjugate base of | ||
label |
benazepril |
|
mass |
424.48950 |
|
monoisotopicmass |
424.19982 |
|
notation |
CHEBI:3011 |
|
prefixIRI |
CHEBI:3011 |
|
prefLabel |
benazepril |
|
smiles |
CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O |
|
textual definition |
A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure. |
|
subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35676 http://purl.obolibrary.org/obo/CHEBI_24995 |