loading...| Preferred Name |
glutathione |
|
| Synonyms |
GSH |
|
| Definitions |
A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C523" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C523" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000655232 |
|
| altLabel |
GSH TAD N-(N-L-gamma-glutamyl-L-cysteinyl)glycine reduced glutathione |
|
| CAS Registry |
70-18-8 |
|
| cui |
C0017817 C0034917 C4082312 |
|
| DATE FIRST PUBLISHED |
2009-09-15 |
|
| Date last modified |
2009-09-15 |
|
| definition |
A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C523" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C523" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C523 |
|
| notation |
CDR0000655232 |
|
| NSC Code |
400639 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
glutathione |
|
| tui |
T116 T123 T034 T121 |