Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

hydroxyurea

Synonyms

HYD

Definitions

A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C560" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C560" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000040685

altLabel

HYD

Hydurea

SQ 1089

Hydrea

HU

Syrea

SQ-1089

Droxia

Oxeron

Oncocarbide

Litalir

Hydroxycarbamide

Onco-Carbide

WR 83799

CAS Registry

127-07-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041074

http://purl.bioontology.org/ontology/PDQ/CDR0000367083

http://purl.bioontology.org/ontology/PDQ/CDR0000041961

http://purl.bioontology.org/ontology/PDQ/CDR0000040284

http://purl.bioontology.org/ontology/PDQ/CDR0000042438

http://purl.bioontology.org/ontology/PDQ/CDR0000039043

http://purl.bioontology.org/ontology/PDQ/CDR0000038846

http://purl.bioontology.org/ontology/PDQ/CDR0000042096

http://purl.bioontology.org/ontology/PDQ/CDR0000039459

http://purl.bioontology.org/ontology/PDQ/CDR0000041073

http://purl.bioontology.org/ontology/PDQ/CDR0000041356

http://purl.bioontology.org/ontology/PDQ/CDR0000038840

http://purl.bioontology.org/ontology/PDQ/CDR0000443025

http://purl.bioontology.org/ontology/PDQ/CDR0000042565

http://purl.bioontology.org/ontology/PDQ/CDR0000038419

http://purl.bioontology.org/ontology/PDQ/CDR0000041355

http://purl.bioontology.org/ontology/PDQ/CDR0000041542

http://purl.bioontology.org/ontology/PDQ/CDR0000041231

http://purl.bioontology.org/ontology/PDQ/CDR0000042568

http://purl.bioontology.org/ontology/PDQ/CDR0000039390

http://purl.bioontology.org/ontology/PDQ/CDR0000042696

http://purl.bioontology.org/ontology/PDQ/CDR0000040399

http://purl.bioontology.org/ontology/PDQ/CDR0000039400

http://purl.bioontology.org/ontology/PDQ/CDR0000041945

http://purl.bioontology.org/ontology/PDQ/CDR0000041962

http://purl.bioontology.org/ontology/PDQ/CDR0000039389

http://purl.bioontology.org/ontology/PDQ/CDR0000042206

http://purl.bioontology.org/ontology/PDQ/CDR0000042564

http://purl.bioontology.org/ontology/PDQ/CDR0000039695

http://purl.bioontology.org/ontology/PDQ/CDR0000042567

http://purl.bioontology.org/ontology/PDQ/CDR0000041413

http://purl.bioontology.org/ontology/PDQ/CDR0000041082

http://purl.bioontology.org/ontology/PDQ/CDR0000041682

http://purl.bioontology.org/ontology/PDQ/CDR0000039329

http://purl.bioontology.org/ontology/PDQ/CDR0000042695

http://purl.bioontology.org/ontology/PDQ/CDR0000041878

http://purl.bioontology.org/ontology/PDQ/CDR0000041872

http://purl.bioontology.org/ontology/PDQ/CDR0000041991

http://purl.bioontology.org/ontology/PDQ/CDR0000039709

http://purl.bioontology.org/ontology/PDQ/CDR0000042566

http://purl.bioontology.org/ontology/PDQ/CDR0000041412

http://purl.bioontology.org/ontology/PDQ/CDR0000041868

cui

C0591617

C1512543

C0729128

C1527301

C0720055

C1512544

C1527300

C0020402

C0729130

C0729129

C1527299

Date last modified

2016-04-06

definition

A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C560" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C560" NCI Thesaurus)

IND Code

7179

38558

937

9235

Legacy PDQ ID

360

LT

TRD

NCI ID

C560

notation

CDR0000040685

NSC Code

32065

ORIG STY

Drug/agent

prefLabel

hydroxyurea

tui

T109

T121

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http://purl.bioontology.org/ontology/CSP/0113-4000 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0113-4000 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.395 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-78100 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-78100 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D006918 MESH CUI
http://purl.bioontology.org/ontology/MESH/D006918 MESH CUI
http://purl.bioontology.org/ontology/MESH/D006918 MESH CUI
http://purl.bioontology.org/ontology/MESH/D006918 MESH LOOM
http://www.co-ode.org/ontologies/galen#Hydroxyurea GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/002635 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002635 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006918 RH-MESH LOOM
http://purl.bioontology.org/ontology/SCTSPA/56602009 SCTSPA CUI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146101 ODAE LOOM
http://purl.bioontology.org/ontology/UATC/L01XX05 ATC CUI
http://sbmi.uth.tmc.edu/ontology/ochv#C0020402 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/216755 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/151871 RXNORM CUI
http://www.drugbank.ca/drugs/DB01005 FTC LOOM
http://stirdf.jst.go.jp/id/200907035920979546 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000007293 NDFRT CUI
http://scdontology.h3abionet.org/ontology/SCDO_0000580 SCDO LOOM
http://purl.bioontology.org/ontology/SCTSPA/387314007 SCTSPA CUI
http://purl.obolibrary.org/obo/CHEBI_44423 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_44423 NIFSTD LOOM
http://purl.bioontology.org/ontology/RCD/h55.. RCD CUI
http://purl.bioontology.org/ontology/RCD/h55.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146101 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146101 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387314007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387314007 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906063694062928 IOBC LOOM
http://purl.bioontology.org/ontology/RCD/x02f6 RCD CUI
http://purl.bioontology.org/ontology/VANDF/4017733 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017733 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/56602009 SNOMEDCT CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C560 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/5552 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/5552 RXNORM LOOM
http://www.gamuts.net/entity#hydroxyurea GAMUTS LOOM
http://purl.bioontology.org/ontology/MSHFRE/D006918 MSHFRE CUI
http://sbmi.uth.tmc.edu/ontology/ochv#6391 OCHV LOOM