loading...| Preferred Name |
probenecid |
|
| Synonyms |
PROB |
|
| Definitions |
A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C772" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C772" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040223 |
|
| altLabel |
PROB Benemid SK-Probenecid |
|
| CAS Registry |
57-66-9 |
|
| Component of | ||
| cui |
C0729110 C0591159 C0033209 |
|
| definition |
A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C772" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C772" NCI Thesaurus) |
|
| Legacy PDQ ID |
3033 |
|
| LT |
TRD |
|
| NCI ID |
C772 |
|
| notation |
CDR0000040223 |
|
| NSC Code |
18786 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
probenecid |
|
| tui |
T109 T121 |