Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

probenecid

Synonyms

PROB

Definitions

A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C772" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C772" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000040223

altLabel

PROB

Benemid

SK-Probenecid

CAS Registry

57-66-9

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000038426

cui

C0033209

C0591159

C0729110

definition

A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C772" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C772" NCI Thesaurus)

Legacy PDQ ID

3033

LT

TRD

NCI ID

C772

notation

CDR0000040223

NSC Code

18786

ORIG STY

Drug/agent

prefLabel

probenecid

tui

T109

T121

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http://purl.obolibrary.org/obo/DRON_00014428 ODNAE LOOM
http://purl.obolibrary.org/obo/DRON_00014428 DRON LOOM
http://purl.bioontology.org/ontology/MSHFRE/D011339 MSHFRE CUI
http://purl.bioontology.org/ontology/CSP/2840-3387 CRISP CUI
http://purl.bioontology.org/ontology/CSP/2840-3387 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011339 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006102 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006102 DMTO LOOM
http://www.bioassayontology.org/bao#BAO_0000998 BAO LOOM
http://www.co-ode.org/ontologies/galen#Probenecid GALEN LOOM
http://purl.bioontology.org/ontology/MESH/D011339 MESH CUI
http://purl.bioontology.org/ontology/MESH/D011339 MESH CUI
http://purl.bioontology.org/ontology/MESH/D011339 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002321 NDDF CUI
http://purl.bioontology.org/ontology/LNC/LP16260-9 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP16260-9 LOINC LOOM
http://www.drugbank.ca/drugs/DB01032 FTC LOOM
http://purl.bioontology.org/ontology/RCD/j63.. RCD CUI
http://purl.bioontology.org/ontology/RCD/j63.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000005795 NDFRT CUI
http://purl.jp/bio/4/id/200906015026554512 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007603 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU007603 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/M04AB01 ATC CUI
http://purl.bioontology.org/ontology/UATC/M04AB01 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387365004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387365004 SNOMEDCT LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#probenecid FASTO LOOM
http://purl.bioontology.org/ontology/SNMI/C-72610 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-72610 SNMI LOOM
http://purl.bioontology.org/ontology/SCTSPA/66094001 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/8698 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/8698 RXNORM LOOM
http://purl.bioontology.org/ontology/SCTSPA/387365004 SCTSPA CUI
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Probenecid APAONTO LOOM
http://purl.bioontology.org/ontology/VANDF/4017872 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017872 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/x02VG RCD CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.625 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146225 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146225 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.625 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/66094001 SNOMEDCT CUI
http://stirdf.jst.go.jp/id/200907013057451135 IOBC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006106 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006106 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006106 DMTO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C772 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8426 DINTO LOOM