loading...| Preferred Name |
propylthiouracil |
|
| Synonyms |
6-Propyl-2-Thiouracil |
|
| Definitions |
A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C781" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C781" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039288 |
|
| altLabel |
6-Propyl-2-Thiouracil |
|
| CAS Registry |
51-52-5 |
|
| cui |
C0033511 |
|
| definition |
A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C781" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C781" NCI Thesaurus) |
|
| Legacy PDQ ID |
1921 |
|
| NCI ID |
C781 |
|
| notation |
CDR0000039288 |
|
| NSC Code |
70461 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
propylthiouracil |
|
| tui |
T114 T121 |