Preferred Name |
imipramine |
|
Synonyms |
|
|
Definitions |
A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62039" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62039" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000792682 |
|
CAS Registry |
50-49-7 |
|
cui |
C0020934 |
|
DATE FIRST PUBLISHED |
2018-03-19 |
|
Date last modified |
2018-03-19 |
|
definition |
A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62039" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62039" NCI Thesaurus) |
|
NCI ID |
C62039 |
|
notation |
CDR0000792682 |
|
NSC Code |
169866 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
imipramine |
|
tui |
T109 T121 |