loading...| Preferred Name |
bumetanide |
|
| Synonyms |
Bumex |
|
| Definitions |
A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28875" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28875" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000788832 |
|
| altLabel |
Bumex |
|
| CAS Registry |
28395-03-1 |
|
| cui |
C0006376 C0701009 |
|
| DATE FIRST PUBLISHED |
2017-05-08 |
|
| Date last modified |
2017-05-08 |
|
| definition |
A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28875" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28875" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C28875 |
|
| notation |
CDR0000788832 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
bumetanide |
|
| tui |
T109 T121 |