Preferred Name |
carvedilol |
|
Synonyms |
Coreg |
|
Definitions |
A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers). Its acts more strongly on beta-receptors than on alpha 1-receptors, reduces peripheral vascular resistance by vasodilation, and prevents reflex tachycardia (beta-blockade) so that heart rate is either unchanged or decreased. Carvedilol also reduces renin release through beta-blockade. |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000700417 |
|
altLabel |
Coreg |
|
CAS Registry |
72956-09-3 |
|
cui |
C0719509 C0054836 |
|
DATE FIRST PUBLISHED |
2011-05-10 |
|
Date last modified |
2011-05-10 |
|
definition |
A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers). Its acts more strongly on beta-receptors than on alpha 1-receptors, reduces peripheral vascular resistance by vasodilation, and prevents reflex tachycardia (beta-blockade) so that heart rate is either unchanged or decreased. Carvedilol also reduces renin release through beta-blockade. |
|
LT |
TRD |
|
notation |
CDR0000700417 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
carvedilol |
|
tui |
T109 T121 |