Preferred Name |
metoprolol |
|
Synonyms |
|
|
Definitions |
A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61845" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000694582 |
|
CAS Registry |
37350-58-6 |
|
cui |
C0025859 |
|
DATE FIRST PUBLISHED |
2011-01-28 |
|
Date last modified |
2011-01-28 |
|
definition |
A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61845" NCI Thesaurus) |
|
NCI ID |
C61845 |
|
notation |
CDR0000694582 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
metoprolol |
|
tui |
T109 T121 |