Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

Richter syndrome
Synonyms

Richter's Syndrome

Richter's transformation

Definitions

Transformation of chronic lymphocytic leukemia into aggressive non-Hodgkin's lymphoma, usually diffuse large B-cell lymphoma (immunoblastic or centroblastic variant). Occasional cases of transformation to Hodgkin's lymphoma have also been described, particularly in patients treated with purine nucleotide analogues. Molecular genetic studies suggest that in approximately half of the cases, the lymphoma is clonally related to the underlying chronic lymphocytic leukemia, whereas in the remaining cases the lymphoma probably represents a secondary, unrelated neoplasm. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C35424" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C35424" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000475631

altLabel

Richter's Syndrome

Richter's transformation

cui

C0349631

DATE FIRST PUBLISHED

2006-03-24

Date last modified

2010-06-10

definition

Transformation of chronic lymphocytic leukemia into aggressive non-Hodgkin's lymphoma, usually diffuse large B-cell lymphoma (immunoblastic or centroblastic variant). Occasional cases of transformation to Hodgkin's lymphoma have also been described, particularly in patients treated with purine nucleotide analogues. Molecular genetic studies suggest that in approximately half of the cases, the lymphoma is clonally related to the underlying chronic lymphocytic leukemia, whereas in the remaining cases the lymphoma probably represents a secondary, unrelated neoplasm. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C35424" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C35424" NCI Thesaurus)

MENU PARENT

neoplastic syndrome

MENU TYPE

Clinical Trials--CancerType

NCI ID

C35424

notation

CDR0000475631

ORIG STY

Neoplasm diagnosis

prefLabel

Richter syndrome

tui

T191

subClassOf

http://purl.bioontology.org/ontology/PDQ/CDR0000475629

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