loading...| Preferred Name |
deferoxamine mesylate |
|
| Synonyms |
Desferal |
|
| Definitions |
The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C417" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C417" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041696 |
|
| altLabel |
Desferal deferoxamine methanesulfonate DFM |
|
| CAS Registry |
138-14-7 |
|
| cui |
C0591350 C0011148 |
|
| Date last modified |
2008-10-15 |
|
| definition |
The mesylate salt of an iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and ferrioxamine, a water-soluble complex excreted by the kidneys and in the feces via the bile. This agent does not readily chelate iron bound to transferrin, hemoglobin, myoglobin or cytochrome. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C417" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C417" NCI Thesaurus) |
|
| Legacy PDQ ID |
4858 |
|
| LT |
TRD |
|
| NCI ID |
C417 |
|
| notation |
CDR0000041696 |
|
| NSC Code |
644468 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
deferoxamine mesylate |
|
| tui |
T109 T130 T121 |