loading...| Preferred Name |
spironolactone |
|
| Synonyms |
SC 9420 |
|
| Definitions |
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C840" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C840" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039444 |
|
| altLabel |
SC 9420 17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate SPL Spiroctan Aldactone |
|
| CAS Registry |
52-01-7 |
|
| cui |
C0591054 C0037982 C0701468 C0592132 |
|
| Date last modified |
2015-10-02 |
|
| definition |
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C840" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C840" NCI Thesaurus) |
|
| IND Code |
11222 |
|
| Legacy PDQ ID |
2079 |
|
| LT |
TRD |
|
| NCI ID |
C840 |
|
| notation |
CDR0000039444 |
|
| NSC Code |
150399 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
spironolactone |
|
| tui |
T109 T121 |