Preferred Name |
Waldenström macroglobulinemia |
|
Synonyms |
Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia |
|
Definitions |
A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein. Lymphoplasmacytic lymphoma/Waldenström's Macroglobulinemia is a relatively rare condition accounting for approximately 2% of hematologic malignancies. Symptoms include: weakness and fatigue, hemorrhagic manifestations, weight loss, and visual disturbances. Physical findings include: hepatomegaly, splenomegaly, fundic changes, adenopathy, neurologic abnormalities, and purpura. The most common laboratory finding is anemia. Treatment includes: chemotherapy (alkylating agents, nucleoside analogues) radiotherapy, and plasmapheresis. Bone marrow transplant is being investigated. Asymptomatic patients may be monitored without treatment until complications occur. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3212" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C3212" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000037790 |
|
altLabel |
Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia macroglobulinemia lymphoplasmacytic lymphoma Waldenström's macroglobulinemia lymphoplasmacytoid lymphoma macroglobulinemia, Waldenström's Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia plasmacytoma, macroglobulinemia |
|
Associated genetic condition | ||
cui |
C0024419 |
|
Date last modified |
2012-03-29 |
|
definition |
A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein. Lymphoplasmacytic lymphoma/Waldenström's Macroglobulinemia is a relatively rare condition accounting for approximately 2% of hematologic malignancies. Symptoms include: weakness and fatigue, hemorrhagic manifestations, weight loss, and visual disturbances. Physical findings include: hepatomegaly, splenomegaly, fundic changes, adenopathy, neurologic abnormalities, and purpura. The most common laboratory finding is anemia. Treatment includes: chemotherapy (alkylating agents, nucleoside analogues) radiotherapy, and plasmapheresis. Bone marrow transplant is being investigated. Asymptomatic patients may be monitored without treatment until complications occur. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3212" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C3212" NCI Thesaurus) |
|
Legacy PDQ ID |
1015 |
|
MENU PARENT |
Disease/diagnosis adult non-Hodgkin lymphoma |
|
MENU TYPE |
Clinical Trials--CancerType |
|
NCI ID |
C3212 |
|
notation |
CDR0000037790 |
|
ORIG STY |
Cancer stage |
|
prefLabel |
Waldenström macroglobulinemia |
|
tui |
T191 |
|
subClassOf |
http://purl.bioontology.org/ontology/PDQ/CDR0000042758 |