Preferred Name |
apical ectodermal ridge |
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Synonyms |
crista ectodermalis apicalis AER apical epidermal ridge |
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Definitions |
multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. |
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ID |
http://purl.obolibrary.org/obo/UBERON_0004356 |
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axiom_lost_from_external_ontology |
relationship loss: subclass proliferative region (TAO:0000098)[TAO] |
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curator note |
note that media, dorsal fins etc have AERs. |
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depicted_by |
http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg |
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developmentally induced by | ||
external_definition |
Proliferative region that is part of the developing fin fold or fin.[TAO] Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO] |
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function_notes |
maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop |
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has_exact_synonym |
apical epidermal ridge |
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has_related_synonym |
crista ectodermalis apicalis AER |
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id |
UBERON:0004356 |
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in_subset | ||
label |
apical ectodermal ridge |
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notation |
UBERON:0004356 |
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part_of | ||
prefLabel |
apical ectodermal ridge |
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taxon_notes |
The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold |
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treeView | ||
数据库_交叉_引用 |
http://en.wikipedia.org/wiki/Apical_ectodermal_ridge http://linkedlifedata.com/resource/umls/id/C1516037 EMAPA:32744 ZFA:0001702 UMLS:C1516037 TAO:0002146 XAO:0004121 AAO:0010760 NCIT:C34109 |
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文本定义 |
multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. |
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有_obo_命名空间 |
uberon |
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subClassOf |