National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Liraglutide

Synonyms

N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide

Victoza

Liraglutide

LIRAGLUTIDE

NN2211

Definitions

A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82239

CAS_Registry

204656-20-2

Chemical_Formula

C172H265N43O51

code

C82239

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis.

FDA_UNII_Code

839I73S42A

FULL_SYN

N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide

Victoza

Liraglutide

LIRAGLUTIDE

NN2211

label

Liraglutide

Legacy_Concept_Name

Liraglutide

PDQ_Closed_Trial_Search_ID

792738

PDQ_Open_Trial_Search_ID

792738

Preferred_Name

Liraglutide

prefixIRI

ncit:C82239

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1456408

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98085

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http://purl.bioontology.org/ontology/VANDF/4029703 VANDF LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0000955 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000180627 NDFRT LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0001545 DMTO LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0001502 DMTO LOOM
http://purl.obolibrary.org/obo/DRON_00019617 DRON LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#DMTO_0001545 FASTO LOOM
http://purl.bioontology.org/ontology/NDDF/010773 NDDF LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#liraglutide SDO LOOM
http://www.drugbank.ca/drugs/DB06655 FTC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/444907006 SNOMEDCT LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#DMTO_0000955 FASTO LOOM
http://scai.fraunhofer.de/AlzheimerOntology#liraglutide ADO LOOM
http://purl.jp/bio/4/id/201006078991307229 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D000069450 MESH LOOM
http://purl.bioontology.org/ontology/UATC/A10BJ02 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_71193 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_71193 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_71193 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C439759 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/475968 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/444828003 SNOMEDCT LOOM