National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Angiotensin II Receptor Antagonist

Synonyms

ARB

Angiotensin Receptor Blockers

Angiotensin II Receptor Blocker

Angiotensin II Receptor Antagonists

Angiotensin II Receptor Antagonist

Definitions

A class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. Although this class of agents is also used in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure, it is primarily used for the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66930

ALT_DEFINITION

A pharmaceutical agent that selectively inhibits angiotensin II receptor activation in the renin-angiotensin-aldosterone system reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. It is primarily used for the reduction of proteinuria and the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy.

code

C66930

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118468

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90259

Contributing_Source

NICHD

DEFINITION

A class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. Although this class of agents is also used in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure, it is primarily used for the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy.

FULL_SYN

ARB

Angiotensin Receptor Blockers

Angiotensin II Receptor Blocker

Angiotensin II Receptor Antagonists

Angiotensin II Receptor Antagonist

Has_NICHD_Parent

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Angiotensin II Receptor Antagonist

Legacy_Concept_Name

Angiotensin_II_Receptor_Antagonist

NICHD_Hierarchy_Term

Angiotensin II Receptor Antagonist

Preferred_Name

Angiotensin II Receptor Antagonist

prefixIRI

ncit:C66930

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C0521942

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C270

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http://purl.bioontology.org/ontology/RCD/x03j2 RCD LOOM
http://purl.obolibrary.org/obo/XCO_0000536 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000536 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000536 XCO LOOM
http://bmi.utah.edu/ontologies/hfontology/C0521942 HFO LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#angiotensin_II_receptor_antagonist SDO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372913009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/734629003 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005304 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005304 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005304 DMTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005301 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005301 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005301 DMTO LOOM