loading...| Preferred Name |
Mifepristone |
|
| Synonyms |
11 Beta-[4-(N,N-dimethylamino)phenyl]-17alpha-(propyl-1-ynyl)-delta-4,9-estradiene-17 beta-ol-3-one 11-((4-dimethylamino) phenyl)-17-Hydroxy-17-(1-propynyl) Estra-4,9- dien-3-one MIFEPRISTONE Mifepristone mifepristone (aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one Korlym Mifegyne Mifeprex RU 486 RU-38486 RU-486 |
|
| Definitions |
A derivative of the synthetic progestin norethindrone with antiprogesterone activity. Mifepristone competitively binds to the progesterone receptor, resulting in inhibition of the effects of endogenous or exogenous progesterone. This agent also exhibits antiglucocorticoid and weak antiandrogenic activities. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C655 |
|
| ALT_DEFINITION |
A drug used to end early pregnancies. It is also being studied in the treatment of some types of cancer and other conditions. Mifepristone blocks the action of progesterone, a hormone that helps some cancers grow. It is a type of antiprogesterone. |
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| CAS_Registry |
84371-65-3 |
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| CHEBI_ID |
CHEBI:50692 |
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| Chemical_Formula |
C29H35NO2 |
|
| code |
C655 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A derivative of the synthetic progestin norethindrone with antiprogesterone activity. Mifepristone competitively binds to the progesterone receptor, resulting in inhibition of the effects of endogenous or exogenous progesterone. This agent also exhibits antiglucocorticoid and weak antiandrogenic activities. |
|
| Display_Name |
Mifepristone |
|
| FDA_UNII_Code |
320T6RNW1F |
|
| FULL_SYN |
11 Beta-[4-(N,N-dimethylamino)phenyl]-17alpha-(propyl-1-ynyl)-delta-4,9-estradiene-17 beta-ol-3-one 11-((4-dimethylamino) phenyl)-17-Hydroxy-17-(1-propynyl) Estra-4,9- dien-3-one MIFEPRISTONE Mifepristone mifepristone (aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one Korlym Mifegyne Mifeprex RU 486 RU-38486 RU-486 |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Mifepristone |
|
| Legacy Concept Name |
Mifepristone |
|
| Maps_To |
Mifepristone |
|
| NCI_Drug_Dictionary_ID |
40888 |
|
| NSC Number |
652104 |
|
| PDQ_Closed_Trial_Search_ID |
40888 |
|
| PDQ_Open_Trial_Search_ID |
40888 |
|
| Preferred_Name |
Mifepristone |
|
| prefixIRI |
Thesaurus:C655 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0026088 |
|
| subClassOf |