National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Metronidazole

Synonyms

Flagyl

metronidazole

Tricom

Flagyl I.V. RTU

Metronidazole

METRONIDAZOLE

Definitions

A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C651

ALT_DEFINITION

A drug that is used to treat infection and is being studied in the treatment of cancer. It is a type of antibacterial, antiprotozoal, and anthelmintic.

CAS_Registry

443-48-1

CHEBI_ID

CHEBI:6909

Chemical_Formula

C6H9N3O3

code

C651

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth.

FDA_UNII_Code

140QMO216E

FULL_SYN

Flagyl

metronidazole

Tricom

Flagyl I.V. RTU

Metronidazole

METRONIDAZOLE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48005

label

Metronidazole

Legacy_Concept_Name

Metronidazole

NSC_Code

50364

69587

Preferred_Name

Metronidazole

prefixIRI

ncit:C651

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0025872

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C279

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C784

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http://purl.bioontology.org/ontology/RXNORM/6922 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6909 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372602008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002300 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Metronidazole GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008795 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002958 NDDF LOOM
http://scdontology.h3abionet.org/ontology/SCDO_0002912 SCDO LOOM
http://stirdf.jst.go.jp/id/200907020376726100 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.308.658.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/A01AB17 ATC LOOM
http://purl.bioontology.org/ontology/LNC/LP14997-8 LOINC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146194 ODAE LOOM
http://purl.bioontology.org/ontology/UATC/G01AF01 ATC LOOM
http://purl.bioontology.org/ontology/UATC/D06BX01 ATC LOOM
http://purl.bioontology.org/ontology/CSP/1549-4919 CRISP LOOM
http://purl.bioontology.org/ontology/SNMI/C-52040 SNMI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146194 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.640.672.500 RH-MESH LOOM
http://purl.jp/bio/4/id/200906013134576937 IOBC LOOM
http://purl.jp/bio/4/id/200906013134576937 IOBC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039503 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4017836 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/P01AB01 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/1222004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/UATC/J01XD01 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D008795 MESH LOOM