National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Terbutaline

Synonyms

Terbutaline

TERBUTALINE

Definitions

An ethanolamine derivative with bronchodilating and tocolytic activities. Terbutaline selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic AMP (cAMP) production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids in the relaxation of airway muscles. Terbutaline also increases mucociliary clearance and reduces release of inflammatory cell mediators.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61965

CAS_Registry

23031-25-6

CHEBI_ID

CHEBI:9449

Chemical_Formula

C12H19NO3

code

C61965

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An ethanolamine derivative with bronchodilating and tocolytic activities. Terbutaline selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic AMP (cAMP) production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids in the relaxation of airway muscles. Terbutaline also increases mucociliary clearance and reduces release of inflammatory cell mediators.

FDA_UNII_Code

N8ONU3L3PG

FULL_SYN

Terbutaline

TERBUTALINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47748

label

Terbutaline

Legacy_Concept_Name

Terbutaline

Preferred_Name

Terbutaline

prefixIRI

ncit:C61965

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0039542

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48149

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C319

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http://purl.bioontology.org/ontology/MESH/D013726 MESH LOOM
http://www.gamuts.net/entity#terbutaline GAMUTS LOOM
http://purl.obolibrary.org/obo/CHEBI_9449 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9449 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9449 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9449 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9449 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9449 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9449 NIFSTD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148026 NDFRT LOOM
http://purl.bioontology.org/ontology/RCD/x01Cq RCD LOOM
http://purl.bioontology.org/ontology/SNMI/C-68120 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4019941 VANDF LOOM
http://webprotege.stanford.edu/RBcYJMcvXAa8dJEHFQpWt8x COPDO LOOM
http://www.co-ode.org/ontologies/galen#Terbutaline GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013726 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00871 FTC LOOM
http://purl.bioontology.org/ontology/LNC/LP17982-7 LOINC LOOM
http://purl.jp/bio/4/id/200906064797878035 IOBC LOOM
http://stirdf.jst.go.jp/id/200907098182869791 IOBC LOOM
http://purl.bioontology.org/ontology/CSP/2268-7300 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/10368 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12108 OCHV LOOM
http://purl.bioontology.org/ontology/UATC/R03AC03 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.100.291.905 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.063.291.905 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/R03CC03 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013595 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372745006 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039542 OCHV LOOM