National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Eprosartan

Synonyms

EPROSARTAN

Eprosartan

Definitions

A competitive and reversible angiotensin II receptor antagonist with anti-hypertensive property. Eprosartan blocks the binding of angiotensin II to the angiotensin (AT)1 receptor in vascular smooth muscle, thereby blocking the principal pressor action of angiotensin II on the renin-angiotensin system resulting in vascular dilatation. In addition, this agent blocks angiotensin II -induced stimulation of aldosterone synthesis and secretion by the adrenal cortex, cardiac contraction, renal resorption of sodium, activity of the sympathetic nervous system, and smooth muscle cell growth. Furthermore, eprosartan inhibits sympathetic norepinephrine production, thereby further reducing blood pressure.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61749

CAS_Registry

133040-01-4

CHEBI_ID

CHEBI:4814

Chemical_Formula

C23H24N2O4S

code

C61749

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A competitive and reversible angiotensin II receptor antagonist with anti-hypertensive property. Eprosartan blocks the binding of angiotensin II to the angiotensin (AT)1 receptor in vascular smooth muscle, thereby blocking the principal pressor action of angiotensin II on the renin-angiotensin system resulting in vascular dilatation. In addition, this agent blocks angiotensin II -induced stimulation of aldosterone synthesis and secretion by the adrenal cortex, cardiac contraction, renal resorption of sodium, activity of the sympathetic nervous system, and smooth muscle cell growth. Furthermore, eprosartan inhibits sympathetic norepinephrine production, thereby further reducing blood pressure.

FDA_UNII_Code

2KH13Z0S0Y

FULL_SYN

EPROSARTAN

Eprosartan

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47515

label

Eprosartan

Legacy_Concept_Name

Eprosartan

Preferred_Name

Eprosartan

prefixIRI

ncit:C61749

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0287041

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66930

Delete Subject Author Type Created
No notes to display