National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Valsartan

Synonyms

VALSARTAN

Diovan

CGP 48933

Valsartan

N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine

L-Valine, N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

Definitions

An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47781

CAS_Registry

137862-53-4

CHEBI_ID

CHEBI:9927

Chemical_Formula

C24H29N5O3

code

C47781

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with antihypertensive properties. Valsartan selectively and competitively blocks the binding of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion, and renal reabsorption of sodium, and resulting in vasodilation, increased excretion of sodium and water, a reduction in plasma volume, and a reduction in blood pressure.

FDA_UNII_Code

80M03YXJ7I

FULL_SYN

VALSARTAN

Diovan

CGP 48933

Valsartan

N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine

L-Valine, N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

label

Valsartan

Legacy_Concept_Name

Valsartan

PDQ_Closed_Trial_Search_ID

464172

PDQ_Open_Trial_Search_ID

464172

Preferred_Name

Valsartan

prefixIRI

ncit:C47781

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0216784

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66930

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http://purl.bioontology.org/ontology/RXNORM/69749 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/69749 NLMVS LOOM
http://purl.obolibrary.org/obo/DRON_00017695 DRON LOOM
http://purl.bioontology.org/ontology/VANDF/4020986 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/C09CA03 ATC LOOM
http://purl.bioontology.org/ontology/RCD/bk4.. RCD LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9927 NIFSTD LOOM
http://bmi.utah.edu/ontologies/hfontology/C0216784 HFO LOOM
http://purl.jp/bio/4/id/200906040213256090 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D000068756 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108581009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000464172 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386876001 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB00177 FTC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005844 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005844 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005844 DMTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C081489 RH-MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005845 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005845 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005845 DMTO LOOM
http://www.co-ode.org/ontologies/galen#Valsartan GALEN LOOM
http://purl.bioontology.org/ontology/LNC/LP171649-9 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/006279 NDDF LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148456 OCVDAE LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148456 NDFRT LOOM